People are roasting each other at parties, at work events, around the fire. It's so fun. People are busting each other's chops, and it's a sign of affection, truly. It's a true test of love and friendship: can you make a man laugh at himself? So what makes a good burn? Go after targets you love and respect. And hit 'em hard.
I had a friend where it turned out that she hated my guts, all through our friendship. I thought she was my best friend, and then, in high school, she turned on me and had sordid affairs with all of the people that I'd dated. It was less hurtful because I was in high school, so it was more like, 'What's wrong with you? Gross!'